Simone De Angelis works on the relationship between literature and knowledge that is gained from culture and the sciences. In this perspective the literary text and the knowledge that it conveys are compared to other sorts of texts and forms of knowledge. In this sense his research follows a comparative and interdisciplinary modus operandi. His research fields cover the history of European literatures, natural and human sciences as well as medicine from the Renaissance and the Enlightenment to Modern Times. He did his PhD on the 18th century physiologist and man of letters Albrecht von Haller focusing on the epistemological and methodological meaning of the use of hypotheses in experimental science. From 2000-2003 he was Fellow of the Swiss National Science Foundation working on the genesis and development of anthropology as a "science of man" in the early modern period. From 2000-2001 he studied the commentaries on Aristotle's De anima in the medical context of the Renaissance at the University of Padua. From 2001-2002 he was Research Fellow at the Wellcome Trust Centre for the History of Medicine at University College London. From 2003-2005 he was Fellow of the Herzog August Bibliothek in Wolfenbüttel. 2008 he obtained his Habilitation in German Studies and Comparative Literature at the University of Bern. In his teaching and research he pursues the difficult dialogue between the "Two Cultures" by analyzing the processes of knowledge transmission, circulation and transformation in textual artefacts and their context.